Squalene synthase
From Proteopedia
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== Function == | == Function == | ||
| - | '''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol. | + | '''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol<ref>PMID:11008488</ref>. |
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
| + | SQS inhibitors are tested for antihyperlipidemic and antiatherosclerotic agents<ref>PMID:21864285</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 09:22, 31 August 2016
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3D structures of squalene synthase
Updated on 31-August-2016
References
- ↑ Tansey TR, Shechter I. Squalene synthase: structure and regulation. Prog Nucleic Acid Res Mol Biol. 2001;65:157-95. PMID:11008488
- ↑ Kourounakis AP, Katselou MG, Matralis AN, Ladopoulou EM, Bavavea E. Squalene synthase inhibitors: An update on the search for new antihyperlipidemic and antiatherosclerotic agents. Curr Med Chem. 2011;18(29):4418-39. PMID:21864285
