Squalene-hopene cyclase
From Proteopedia
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== Function == | == Function == | ||
| - | '''Squalene-hopene cyclase''' (SHC) catalyzes the conversion of acyclic squalene into the pentacyclic hopene and hopanol in prokaryotes. The reaction which SHC cactalyzes involves the breaking or forming of 13 covalent bonds, the formation of 9 chiral centers and the formation of 5 rings in a single step. | + | '''Squalene-hopene cyclase''' (SHC) catalyzes the conversion of acyclic squalene into the pentacyclic hopene and hopanol in prokaryotes. The reaction which SHC cactalyzes involves the breaking or forming of 13 covalent bonds, the formation of 9 chiral centers and the formation of 5 rings in a single step<ref>PMID:25503928</ref>. |
== Disease == | == Disease == | ||
Revision as of 10:14, 31 August 2016
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3D structures of squalene-hopene cyclase
Updated on 31-August-2016
References
- ↑ Hammer SC, Marjanovic A, Dominicus JM, Nestl BM, Hauer B. Squalene hopene cyclases are protonases for stereoselective Bronsted acid catalysis. Nat Chem Biol. 2015 Feb;11(2):121-6. doi: 10.1038/nchembio.1719. Epub 2014 Dec, 15. PMID:25503928 doi:http://dx.doi.org/10.1038/nchembio.1719
