Phosphoenolpyruvate carboxykinase

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== Structural highlights ==
== Structural highlights ==
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''E. coli'' GTP-driven PEPCK active site is located in a pocket at the enzyme surface<ref>PMID:11851336</ref>.
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''E. coli'' GTP-driven PEPCK <scene name='54/540171/Cv/4'>active site</scene> is located in a pocket at the enzyme surface<ref>PMID:11851336</ref>. Water molecules shown as red spheres.
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*<scene name='54/540171/Cv/6'>Mn coordination site</scene>.
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*<scene name='54/540171/Cv/8'>Na coordination site</scene>.
</StructureSection>
</StructureSection>

Revision as of 12:48, 31 August 2016

GTP-driven E. coli PEPCK complex with PEP, ethanediol, Na+ (purple) and Mn+2 ions (PDB entry 1khf)

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3D Structures of PEPCK

Updated on 31-August-2016

References

  1. Hanson RW, Reshef L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu Rev Biochem. 1997;66:581-611. PMID:9242918 doi:http://dx.doi.org/10.1146/annurev.biochem.66.1.581
  2. Dunten P, Belunis C, Crowther R, Hollfelder K, Kammlott U, Levin W, Michel H, Ramsey GB, Swain A, Weber D, Wertheimer SJ. Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. J Mol Biol. 2002 Feb 15;316(2):257-64. PMID:11851336 doi:http://dx.doi.org/10.1006/jmbi.2001.5364

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