Symporter
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='4d2c' size='340' side='right' caption='Di-or tripeptide:H+ symporter (grey) complex with dipeptide (green), lipid and phosphate (PDB code [[4d2c]])' scene=''> |
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== Function == | == Function == | ||
| + | Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>. | ||
== Disease == | == Disease == | ||
| - | + | Mutations in sodium/iodide symporter cause iodide transport defects<ref>PMID:10403177</ref>. | |
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== Structural highlights == | == Structural highlights == | ||
| - | + | Dipeptide:H symporter binds the dipeptide between its N- and C-terminal bundles<ref>PMID:24916388</ref>. | |
</StructureSection> | </StructureSection> | ||
Revision as of 08:23, 6 September 2016
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3D Structures of symporter
Updated on 06-September-2016
References
- ↑ Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003 Feb;24(1):48-77. PMID:12588808 doi:http://dx.doi.org/10.1210/er.2001-0029
- ↑ Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie. 1999 May;81(5):469-76. PMID:10403177
- ↑ Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, Caffrey M, Newstead S. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep. 2014 Jun 10. pii: e201338403. PMID:24916388 doi:http://dx.doi.org/10.15252/embr.201338403
