Talin
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_2x0c| PDB=2x0c | SIZE=400| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }} | {{STRUCTURE_2x0c| PDB=2x0c | SIZE=400| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }} | ||
| - | [[Talin]] is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 | + | [[Talin]] is involved in cell-cell contacts. It links integrins to actin<ref>PMID:19416068</ref>. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomain interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3. |
== 3D Structures of Talin == | == 3D Structures of Talin == | ||
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**[[2g35]] - mTal F3+PIP kinase peptide – NMR | **[[2g35]] - mTal F3+PIP kinase peptide – NMR | ||
| - | * | + | *Talin layilin-binding sites |
**[[2k00]] - cTal F3+layilin fragment – NMR | **[[2k00]] - cTal F3+layilin fragment – NMR | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Revision as of 09:45, 6 September 2016
Talin is involved in cell-cell contacts. It links integrins to actin[1]. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomain interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3.
3D Structures of Talin
Updated on 06-September-2016
References
- ↑ Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. PMID:19416068 doi:http://dx.doi.org/10.1146/annurev.biophys.050708.133744
