T-cell receptor
From Proteopedia
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{{STRUCTURE_2xna| PDB=2xna | SIZE=400| SCENE= |right|CAPTION= T-cell receptor α chain (grey), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].}} | {{STRUCTURE_2xna| PDB=2xna | SIZE=400| SCENE= |right|CAPTION= T-cell receptor α chain (grey), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].}} | ||
| + | == Function == | ||
| + | '''T-cell receptors''' (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes<ref>PMID:17624994</ref>. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits. TCR NKT reside in Natural Killer T-cells. For more details see [[SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex]]. | ||
| - | + | == Relevance == | |
| + | Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells<ref>PMID:22610778</ref>. This technique is currently developed by several biotechnology companies and implemented in therapy. | ||
== 3D structures of T-cell receptor== | == 3D structures of T-cell receptor== | ||
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| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:38, 7 September 2016
Contents |
Function
T-cell receptors (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes[1]. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits. TCR NKT reside in Natural Killer T-cells. For more details see SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex.
Relevance
Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells[2]. This technique is currently developed by several biotechnology companies and implemented in therapy.
3D structures of T-cell receptor
Updated on 07-September-2016
References
- ↑ Kang L, Sebastian BM, Pritchard MT, Pratt BT, Previs SF, Nagy LE. Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. Alcohol Clin Exp Res. 2007 Sep;31(9):1581-8. Epub 2007 Jul 11. PMID:17624994 doi:http://dx.doi.org/10.1111/j.1530-0277.2007.00452.x
- ↑ Uttenthal BJ, Chua I, Morris EC, Stauss HJ. Challenges in T cell receptor gene therapy. J Gene Med. 2012 Jun;14(6):386-99. doi: 10.1002/jgm.2637. PMID:22610778 doi:http://dx.doi.org/10.1002/jgm.2637
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