1ocn
From Proteopedia
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|PDB= 1ocn |SIZE=350|CAPTION= <scene name='initialview01'>1ocn</scene>, resolution 1.31Å | |PDB= 1ocn |SIZE=350|CAPTION= <scene name='initialview01'>1ocn</scene>, resolution 1.31Å | ||
|SITE= <scene name='pdbsite=ACI:Ca+Binding+Site+For+Chain+A'>ACI</scene> | |SITE= <scene name='pdbsite=ACI:Ca+Binding+Site+For+Chain+A'>ACI</scene> | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IFM:5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE'>IFM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ocn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ocn OCA], [http://www.ebi.ac.uk/pdbsum/1ocn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ocn RCSB]</span> | ||
}} | }} | ||
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[[Category: Stick, R V.]] | [[Category: Stick, R V.]] | ||
[[Category: Varrot, A.]] | [[Category: Varrot, A.]] | ||
| - | [[Category: BGC]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: IFM]] | ||
| - | [[Category: NAG]] | ||
[[Category: cellobiohydrolase]] | [[Category: cellobiohydrolase]] | ||
[[Category: cellulase]] | [[Category: cellulase]] | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:43:19 2008'' |
Revision as of 19:43, 30 March 2008
| |||||||
| , resolution 1.31Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , , | ||||||
| Activity: | Cellulose 1,4-beta-cellobiosidase, with EC number 3.2.1.91 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION
Overview
A cellobio-derived isofagomine glycosidase inhibitor (Ki approximately 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.
About this Structure
1OCN is a Single protein structure of sequence from Humicola insolens. Full crystallographic information is available from OCA.
Reference
Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases., Varrot A, Macdonald J, Stick RV, Pell G, Gilbert HJ, Davies GJ, Chem Commun (Camb). 2003 Apr 21;(8):946-7. PMID:12744312
Page seeded by OCA on Sun Mar 30 22:43:19 2008
