|
|
| Line 1: |
Line 1: |
| - | | + | #REDIRECT [[5jod]] This PDB entry is obsolete and replaced by 5jod |
| - | ==Structure of proplasmepsin IV from Plasmodium falciparum==
| + | |
| - | <StructureSection load='4y7h' size='340' side='right' caption='[[4y7h]], [[Resolution|resolution]] 1.62Å' scene=''>
| + | |
| - | == Structural highlights ==
| + | |
| - | <table><tr><td colspan='2'>[[4y7h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y7H FirstGlance]. <br>
| + | |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y7h OCA], [http://pdbe.org/4y7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y7h RCSB], [http://www.ebi.ac.uk/pdbsum/4y7h PDBsum]</span></td></tr>
| + | |
| - | </table>
| + | |
| - | <div style="background-color:#fffaf0;">
| + | |
| - | == Publication Abstract from PubMed ==
| + | |
| - | Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase used by Plasmodiumfalciparum to digest hemoglobin during the blood stage of malaria. A large shift between the N-domain and the central and C-domains of proplasmepsin II opens the active site cleft, preventing the formation of a functional aspartic proteinase active site. This mode of inhibition of catalytic activity has not been observed in any other aspartic proteinase zymogen. Instead of occluding a pre-formed active site, as in the gastric aspartic proteinase zymogens, the prosegment of proplasmepsin II interacts extensively with the C-domain and serves as a 'harness' to keep the domains apart. Disruption of key salt bridges at low pH may be important in activation.
| + | |
| - | | + | |
| - | Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum.,Bernstein NK, Cherney MM, Loetscher H, Ridley RG, James MN Nat Struct Biol. 1999 Jan;6(1):32-7. PMID:9886289<ref>PMID:9886289</ref>
| + | |
| - | | + | |
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
| + | |
| - | </div>
| + | |
| - | <div class="pdbe-citations 4y7h" style="background-color:#fffaf0;"></div>
| + | |
| - | == References ==
| + | |
| - | <references/>
| + | |
| - | __TOC__
| + | |
| - | </StructureSection>
| + | |
| - | [[Category: Akopjana, I]]
| + | |
| - | [[Category: Jaudzems, K]]
| + | |
| - | [[Category: Recacha, R]]
| + | |
| - | [[Category: Tars, K]]
| + | |
| - | [[Category: Hydrolase]]
| + | |
| - | [[Category: Malaria]]
| + | |
