5kiz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5kiz" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5kiz is ON HOLD until Aug 12 2017
+
==Solution Structure of a repacked version of HIF-2 alpha PAS-B==
-
 
+
<StructureSection load='5kiz' size='340' side='right' caption='[[5kiz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-
Authors: Correa, F., Key, J., Kuhlman, B., Gardner, K.H.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5kiz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KIZ FirstGlance]. <br>
-
Description: Solution Structure of a repacked version of HIF-2 alpha PAS-B (CASP target)
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kiz OCA], [http://pdbe.org/5kiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kiz RCSB], [http://www.ebi.ac.uk/pdbsum/5kiz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kiz ProSAT]</span></td></tr>
-
[[Category: Unreleased Structures]]
+
</table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/EPAS1_HUMAN EPAS1_HUMAN]] Defects in EPAS1 are the cause of familial erythrocytosis type 4 (ECYT4) [MIM:[http://omim.org/entry/611783 611783]]. ECYT4 is an autosomal dominant disorder characterized by increased serum red blood cell mass, elevated hemoglobin concentration and hematocrit, and normal platelet and leukocyte counts.<ref>PMID:19208626</ref> <ref>PMID:18378852</ref> <ref>PMID:18184961</ref> <ref>PMID:22367913</ref>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/EPAS1_HUMAN EPAS1_HUMAN]] Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Correa, F]]
[[Category: Correa, F]]
 +
[[Category: Gardner, K H]]
 +
[[Category: Key, J]]
[[Category: Kuhlman, B]]
[[Category: Kuhlman, B]]
-
[[Category: Key, J]]
+
[[Category: Cavity]]
-
[[Category: Gardner, K.H]]
+
[[Category: Repacking]]
 +
[[Category: Rosetta]]
 +
[[Category: Transcription]]

Revision as of 00:07, 10 September 2016

Solution Structure of a repacked version of HIF-2 alpha PAS-B

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5kiz"
Personal tools