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5imw

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'''Unreleased structure'''
 
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The entry 5imw is ON HOLD until Paper Publication
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==Trapped Toxin==
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<StructureSection load='5imw' size='340' side='right' caption='[[5imw]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5imw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IMW FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5imw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5imw OCA], [http://pdbe.org/5imw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5imw RCSB], [http://www.ebi.ac.uk/pdbsum/5imw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5imw ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cholesterol-dependent cytolysins (CDCs) are a family of pore-forming toxins that punch holes in the outer membrane of eukaryotic cells. Cholesterol serves as the receptor, but a subclass of CDCs first binds to human CD59. Here we describe the crystal structures of vaginolysin and intermedilysin complexed to CD59. These studies, together with small-angle X-ray scattering, reveal that CD59 binds to each at different, though overlapping, sites, consistent with molecular dynamics simulations and binding studies. The CDC consensus undecapeptide motif, which for the CD59-responsive CDCs has a proline instead of a tryptophan in the motif, adopts a strikingly different conformation between the structures; our data suggest that the proline acts as a selectivity switch to ensure CD59-dependent CDCs bind their protein receptor first in preference to cholesterol. The structural data suggest a detailed model of how these water-soluble toxins assemble as prepores on the cell surface.
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Authors: Lawrence, S.L., Feil, S.C., Morton, C.J., Parker, M.W.
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Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.,Lawrence SL, Gorman MA, Feil SC, Mulhern TD, Kuiper MJ, Ratner AJ, Tweten RK, Morton CJ, Parker MW Structure. 2016 Sep 6;24(9):1488-1498. doi: 10.1016/j.str.2016.06.017. Epub 2016 , Aug 4. PMID:27499440<ref>PMID:27499440</ref>
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Description: Trapped Toxin
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Feil, S.C]]
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<div class="pdbe-citations 5imw" style="background-color:#fffaf0;"></div>
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[[Category: Lawrence, S.L]]
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== References ==
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[[Category: Parker, M.W]]
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<references/>
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[[Category: Morton, C.J]]
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__TOC__
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</StructureSection>
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[[Category: Feil, S C]]
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[[Category: Lawrence, S L]]
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[[Category: Morton, C J]]
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[[Category: Parker, M W]]
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[[Category: Locked]]
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[[Category: Toxin]]

Revision as of 06:51, 10 September 2016

Trapped Toxin

5imw, resolution 2.89Å

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