5ljn

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m (Protected "5ljn" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5ljn is ON HOLD
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==Structure of the HOIP PUB domain bound to SPATA2 PIM peptide==
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<StructureSection load='5ljn' size='340' side='right' caption='[[5ljn]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ljn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LJN FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ljn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ljn OCA], [http://pdbe.org/5ljn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ljn RCSB], [http://www.ebi.ac.uk/pdbsum/5ljn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ljn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RNF31_HUMAN RNF31_HUMAN]] E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.<ref>PMID:17006537</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref> <ref>PMID:22863777</ref> [[http://www.uniprot.org/uniprot/SPAT2_HUMAN SPAT2_HUMAN]] May have a role in the regulation of spermatogenesis.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Elliott, P R]]
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[[Category: Komander, D]]
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[[Category: Ligase]]
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[[Category: Pub domain]]

Revision as of 06:55, 10 September 2016

Structure of the HOIP PUB domain bound to SPATA2 PIM peptide

5ljn, resolution 2.70Å

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