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5kbd
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural Studies of Transcription Factor p73 DNA Binding Domain Bound to PA26 20-mer Response Element== | |
| - | + | <StructureSection load='5kbd' size='340' side='right' caption='[[5kbd]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5kbd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KBD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kd3|5kd3]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kbd OCA], [http://pdbe.org/5kbd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kbd RCSB], [http://www.ebi.ac.uk/pdbsum/5kbd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kbd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Huang, D]] | [[Category: Huang, D]] | ||
| - | [[Category: Nguyen, H | + | [[Category: Nguyen, H T]] |
| + | [[Category: Dna binding protein-dna complex]] | ||
| + | [[Category: Tumor suppressor transcription factor p53 response element]] | ||
Revision as of 13:57, 10 September 2016
Structural Studies of Transcription Factor p73 DNA Binding Domain Bound to PA26 20-mer Response Element
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