5ddz
From Proteopedia
(Difference between revisions)
Line 1: | Line 1: | ||
- | '''Unreleased structure''' | ||
- | + | ==Crystal stucture of the RTA-c10-P2 complex== | |
- | + | <StructureSection load='5ddz' size='340' side='right' caption='[[5ddz]], [[Resolution|resolution]] 1.50Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[5ddz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DDZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DDZ FirstGlance]. <br> | |
- | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr> | |
- | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ddz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ddz OCA], [http://pdbe.org/5ddz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ddz RCSB], [http://www.ebi.ac.uk/pdbsum/5ddz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ddz ProSAT]</span></td></tr> |
+ | </table> | ||
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity). [[http://www.uniprot.org/uniprot/RLA2_HUMAN RLA2_HUMAN]] Plays an important role in the elongation step of protein synthesis.[HAMAP-Rule:MF_01478] | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: RRNA N-glycosylase]] | ||
+ | [[Category: Fan, X]] | ||
+ | [[Category: Li, X]] | ||
+ | [[Category: Niu, L]] | ||
[[Category: Teng, M]] | [[Category: Teng, M]] | ||
- | [[Category: | + | [[Category: Wang, C]] |
[[Category: Zhu, Y]] | [[Category: Zhu, Y]] | ||
- | [[Category: | + | [[Category: Complex]] |
- | [[Category: | + | [[Category: Hydrolase-peptide complex]] |
- | [[Category: | + | [[Category: P2]] |
+ | [[Category: Ricin]] |
Revision as of 21:03, 10 September 2016
Crystal stucture of the RTA-c10-P2 complex
|
Categories: RRNA N-glycosylase | Fan, X | Li, X | Niu, L | Teng, M | Wang, C | Zhu, Y | Complex | Hydrolase-peptide complex | P2 | Ricin