5ei3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.== | |
| - | + | <StructureSection load='5ei3' size='340' side='right' caption='[[5ei3]], [[Resolution|resolution]] 1.71Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ei3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EI3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5O8:~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-AZANYL-6-OXIDANYLIDENE-7-(PHENYLMETHYL)-1~{H}-PURIN-7-IUM-9-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL]-1,1,1-TRIS(FLUORANYL)METHANESULFONAMIDE'>5O8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ei3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ei3 OCA], [http://pdbe.org/5ei3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ei3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ei3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ei3 ProSAT]</span></td></tr> |
| - | [[Category: Nowicki, M | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fischer, P M]] | ||
| + | [[Category: Nowicki, M W]] | ||
| + | [[Category: Walkinshaw, M D]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Eif4e]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Translation]] | ||
Revision as of 21:03, 10 September 2016
Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
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