5ekv
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.== | |
| - | + | <StructureSection load='5ekv' size='340' side='right' caption='[[5ekv]], [[Resolution|resolution]] 3.61Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ekv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EKV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5PQ:3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-AZANYL-7-METHYL-6-OXIDANYLIDENE-1~{H}-PURIN-7-IUM-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYLAMINO]-4-OXIDANYL-CYCLOBUT-3-ENE-1,2-DIONE'>5PQ</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ekv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ekv OCA], [http://pdbe.org/5ekv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ekv RCSB], [http://www.ebi.ac.uk/pdbsum/5ekv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ekv ProSAT]</span></td></tr> |
| - | [[Category: Nowicki, M | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> [[http://www.uniprot.org/uniprot/4EBP1_HUMAN 4EBP1_HUMAN]] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<ref>PMID:7935836</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fischer, P M]] | ||
| + | [[Category: Nowicki, M W]] | ||
| + | [[Category: Walkinshaw, M D]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Eif4e]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Translation]] | ||
Revision as of 21:04, 10 September 2016
Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
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