5i56
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Agonist-bound GluN1/GluN2A agonist binding domains with TCN201== | |
| - | + | <StructureSection load='5i56' size='340' side='right' caption='[[5i56]], [[Resolution|resolution]] 2.28Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5i56]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I56 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=67P:N-({4-[2-(BENZENECARBONYL)HYDRAZINECARBONYL]PHENYL}METHYL)-3-CHLORO-4-FLUOROBENZENE-1-SULFONAMIDE'>67P</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i59|5i59]], [[5i58|5i58]], [[5i57|5i57]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i56 OCA], [http://pdbe.org/5i56 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i56 RCSB], [http://www.ebi.ac.uk/pdbsum/5i56 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i56 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> [[http://www.uniprot.org/uniprot/NMDE1_RAT NMDE1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hansen, K B]] | ||
| + | [[Category: Mou, T C]] | ||
| + | [[Category: Sprang, S R]] | ||
| + | [[Category: Antagonist]] | ||
| + | [[Category: Nmda receptor]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 21:07, 10 September 2016
Agonist-bound GluN1/GluN2A agonist binding domains with TCN201
| |||||||||||
