5k09
From Proteopedia
(Difference between revisions)
m (Protected "5k09" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | ''' | + | {{Large structure}} |
| - | + | ==Crystal Structure of COMT in complex with a thiazole ligand== | |
| - | + | <StructureSection load='5k09' size='340' side='right' caption='[[5k09]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5k09]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K09 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PQ:5-{3-[(4-METHOXYPHENYL)METHYL]-1H-PYRAZOL-5-YL}-2,4-DIMETHYL-1,3-THIAZOLE'>6PQ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k09 OCA], [http://pdbe.org/5k09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k09 RCSB], [http://www.ebi.ac.uk/pdbsum/5k09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k09 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | {{Large structure}} | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Catechol O-methyltransferase]] | ||
[[Category: Ehler, A]] | [[Category: Ehler, A]] | ||
| - | [[Category: | + | [[Category: RODRIGUEZ-SARMIENTO, R M]] |
| - | [[Category: Rudolph, M | + | [[Category: Rudolph, M G]] |
| + | [[Category: Catechol]] | ||
| + | [[Category: Methyltransferase]] | ||
| + | [[Category: Neurotransmitter degradation]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 21:10, 10 September 2016
Warning: this is a large structure, and loading might take a long time or not happen at all.
Crystal Structure of COMT in complex with a thiazole ligand
| |||||||||||
