5k0e
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of COMT in complex with 2,4-dimethyl-5-[3-(2-phenylpropan-2-yl)-1H-pyrazol-5-yl]-1,3-thiazole== | |
| - | + | <StructureSection load='5k0e' size='340' side='right' caption='[[5k0e]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5k0e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K0E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K0E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OZ:2,4-DIMETHYL-5-[3-(2-PHENYLPROPAN-2-YL)-1H-PYRAZOL-5-YL]-1,3-THIAZOLE'>6OZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k0e OCA], [http://pdbe.org/5k0e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k0e RCSB], [http://www.ebi.ac.uk/pdbsum/5k0e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k0e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/COMT_RAT COMT_RAT]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Catechol O-methyltransferase]] | ||
[[Category: Ehler, A]] | [[Category: Ehler, A]] | ||
| - | [[Category: | + | [[Category: RODRIGUEZ-SARMIENTO, R M]] |
| - | [[Category: Rudolph, M | + | [[Category: Rudolph, M G]] |
| + | [[Category: Catechol]] | ||
| + | [[Category: Methyltransferase]] | ||
| + | [[Category: Neurotransmitter degradation]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 21:10, 10 September 2016
Crystal Structure of COMT in complex with 2,4-dimethyl-5-[3-(2-phenylpropan-2-yl)-1H-pyrazol-5-yl]-1,3-thiazole
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