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5l36

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m (Protected "5l36" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5l36 is ON HOLD
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==Crystal Structure of a human FasL mutant in complex with human DcR3==
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<StructureSection load='5l36' size='340' side='right' caption='[[5l36]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors: Liu, W., Bonanno, J.B., Almo, S.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5l36]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L36 FirstGlance]. <br>
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Description: Crystal Structure of a human FasL mutant in complex with human DcR3
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5l19|5l19]], [[4msv|4msv]]</td></tr>
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[[Category: Almo, S.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l36 OCA], [http://pdbe.org/5l36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l36 RCSB], [http://www.ebi.ac.uk/pdbsum/5l36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l36 ProSAT]</span></td></tr>
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[[Category: Bonanno, J.B]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Autoimmune lymphoproliferative syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> [[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.<ref>PMID:17557115</ref> The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.<ref>PMID:17557115</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Almo, S C]]
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[[Category: Bonanno, J B]]
[[Category: Liu, W]]
[[Category: Liu, W]]
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[[Category: Apoptosis]]
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[[Category: Cd95l]]
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[[Category: Dcr3]]
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[[Category: Decoy receptor]]
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[[Category: Fasl]]
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[[Category: Tnf ligand and receptor]]

Revision as of 21:14, 10 September 2016

Crystal Structure of a human FasL mutant in complex with human DcR3

5l36, resolution 3.10Å

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