Thiol:disulfide interchange protein
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='1eej' size=' | + | <StructureSection load='1eej' size='340' side='right' caption='E. coli DsbC complex with MES (PDB code [[1eej]])' scene=''> |
== Function == | == Function == | ||
'''Thiol:disulfide interchange protein''' (DsbC) is a prokaryotic disulfide bond isomerase. <br /> | '''Thiol:disulfide interchange protein''' (DsbC) is a prokaryotic disulfide bond isomerase. <br /> | ||
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*'''DsbE''' catalyzes the reductive step in the assembly of periplasmic c-type cytochrome<ref>PMID:14597624</ref>. <br /> | *'''DsbE''' catalyzes the reductive step in the assembly of periplasmic c-type cytochrome<ref>PMID:14597624</ref>. <br /> | ||
*'''DsbG''' provides reducing equivalents to rescue oxidatively-damaged secreted proteins<ref>PMID:9654144</ref>. | *'''DsbG''' provides reducing equivalents to rescue oxidatively-damaged secreted proteins<ref>PMID:9654144</ref>. | ||
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| - | == Disease == | ||
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| - | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
| - | DsbC active site contains a | + | DsbC active site contains a CXXC motif which modulates the disulfide isomerization and protein folding in the bacterial periplasmic space<ref>PMID:11208797</ref>. |
</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| + | *Thiol:disulfide interchange protein (DsbA) see [[Protein disulfide oxidoreductase]] | ||
* Thiol:disulfide interchange protein (DsbC) | * Thiol:disulfide interchange protein (DsbC) | ||
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**[[1jzd]] – EcDsbC (mutant) + DsbD N terminal<BR /> | **[[1jzd]] – EcDsbC (mutant) + DsbD N terminal<BR /> | ||
**[[1t3b]] – DsbC – ''Haemophilus influenzae'' <BR /> | **[[1t3b]] – DsbC – ''Haemophilus influenzae'' <BR /> | ||
| - | **[[4fyb]], [[4fyc]] – | + | **[[4fyb]], [[4fyc]] – HpDsbC – ''Helicobacter pylori'' <BR /> |
**[[4i5q]] – StDsbC – ''Salmonella typhimurium''<BR /> | **[[4i5q]] – StDsbC – ''Salmonella typhimurium''<BR /> | ||
**[[4ilf]] – StDsbC (mutant) <BR /> | **[[4ilf]] – StDsbC (mutant) <BR /> | ||
| + | **[[4np]] – DsbC –'' Yersinia pestis'' <BR / | ||
*Thiol:disulfide interchange protein (DsbD) | *Thiol:disulfide interchange protein (DsbD) | ||
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**[[1v57]], [[1v58]] – EcDsbG <BR /> | **[[1v57]], [[1v58]] – EcDsbG <BR /> | ||
| - | **[[2h0g]], [[2h0h]], [[2h0i]] – EcDsbG (mutant) <BR /> | + | **[[2h0g]], [[2h0h]], [[2h0i]], [[5g1k]], [[5g1l] – EcDsbG (mutant) <BR /> |
**[[2iy2]] – EcDsbG N terminal<BR /> | **[[2iy2]] – EcDsbG N terminal<BR /> | ||
| + | **[[4ihu]] – MtDsbG <BR /> | ||
| + | **[[3tdg]] – HpDsbG<BR /> | ||
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| + | *Thiol:disulfide interchange protein (DsbP) | ||
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| + | **[[4ml1]], [[4ml6]], [[4mly]] – DsbP – ''Klebsiella pneumoniae'' <BR /> | ||
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}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 08:37, 12 September 2016
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3D Structures of thiol:disulfide interchange protein
Updated on 12-September-2016 {{#tree:id=OrganizedByTopic|openlevels=0|
- Thiol:disulfide interchange protein (DsbA) see Protein disulfide oxidoreductase
- Thiol:disulfide interchange protein (DsbC)
- 1eej, 1tjd – EcDsbC – Escherichal coli
- 1g0t, 1jzo – EcDsbC (mutant)
- 2iyj – EcDsbC N terminal
- 1jzd – EcDsbC (mutant) + DsbD N terminal
- 1t3b – DsbC – Haemophilus influenzae
- 4fyb, 4fyc – HpDsbC – Helicobacter pylori
- 4i5q – StDsbC – Salmonella typhimurium
- 4ilf – StDsbC (mutant)
- 4np – DsbC – Yersinia pestis <BR /
- 1eej, 1tjd – EcDsbC – Escherichal coli
- Thiol:disulfide interchange protein (DsbD)
- 1l6p, 1jpe, 3pfu – EcDsbD N terminal
- 1uc7, 2fwe, 2fwf 2fwg, 2fwh – EcDsbD C terminal
- 4ip1, 4ip6 – EcDsbD C terminal (mutant)
- 1vrs – EcDsbD N terminal (mutant) + C terminal (mutant)
- 1z5y – EcDsbD N terminal (mutant) + EcDsbE soluble domain (mutant)
- 2k0r – NmDsbD N terminal – Neisseria meningitis
- 2k9f – NmDsbD N terminal + thoredoxin
- 1l6p, 1jpe, 3pfu – EcDsbD N terminal
- Thiol:disulfide interchange protein (DsbE)
- Thiol:disulfide interchange protein (DsbG)
- Thiol:disulfide interchange protein (DsbP)
}}
References
- ↑ Rietsch A, Bessette P, Georgiou G, Beckwith J. Reduction of the periplasmic disulfide bond isomerase, DsbC, occurs by passage of electrons from cytoplasmic thioredoxin. J Bacteriol. 1997 Nov;179(21):6602-8. PMID:9352906
- ↑ Chung J, Chen T, Missiakas D. Transfer of electrons across the cytoplasmic membrane by DsbD, a membrane protein involved in thiol-disulphide exchange and protein folding in the bacterial periplasm. Mol Microbiol. 2000 Mar;35(5):1099-109. PMID:10712691
- ↑ Goulding CW, Apostol MI, Gleiter S, Parseghian A, Bardwell J, Gennaro M, Eisenberg D. Gram-positive DsbE proteins function differently from Gram-negative DsbE homologs. A structure to function analysis of DsbE from Mycobacterium tuberculosis. J Biol Chem. 2004 Jan 30;279(5):3516-24. Epub 2003 Nov 3. PMID:14597624 doi:10.1074/jbc.M311833200
- ↑ van Straaten M, Missiakas D, Raina S, Darby NJ. The functional properties of DsbG, a thiol-disulfide oxidoreductase from the periplasm of Escherichia coli. FEBS Lett. 1998 May 29;428(3):255-8. PMID:9654144
- ↑ Bessette PH, Qiu J, Bardwell JC, Swartz JR, Georgiou G. Effect of sequences of the active-site dipeptides of DsbA and DsbC on in vivo folding of multidisulfide proteins in Escherichia coli. J Bacteriol. 2001 Feb;183(3):980-8. PMID:11208797 doi:http://dx.doi.org/10.1128/JB.183.3.980-988.2001
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