Thiolase
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_2iik| PDB=2iik | SIZE=400| SCENE=Thiolase/Thiolase/2 |right|CAPTION=Human 3-ketoacyl-CoA thiolase dimer, [[2iik]] }} | {{STRUCTURE_2iik| PDB=2iik | SIZE=400| SCENE=Thiolase/Thiolase/2 |right|CAPTION=Human 3-ketoacyl-CoA thiolase dimer, [[2iik]] }} | ||
| - | Two different classes of '''thiolases''' are found . | + | Two different classes of '''thiolases''' are found.<br /> |
| + | *'''Degrative thiolase''' like '''3-ketoacyl-CoA thiolase''' (KCT) is involved in fatty acid β oxidation<ref>PMID:16630629</ref><.<br /> | ||
| + | *'''Biosynthetic thiolases''' like '''acetoacetyl-CoA thiolase''' (ACT) are involved in the thiolysis of acetoacetyl-CoA<ref>PMID:21908473</ref><. | ||
| - | For Bacterial | + | For Bacterial thiolase see [[Bacterial thiolase]] |
== 3D Structures of Thiolase == | == 3D Structures of Thiolase == | ||
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**[[4dd5]], [[4e1l]] – ACT – ''Clostridium difficile''<br /> | **[[4dd5]], [[4e1l]] – ACT – ''Clostridium difficile''<br /> | ||
}} | }} | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:09, 12 September 2016
Two different classes of thiolases are found.
- Degrative thiolase like 3-ketoacyl-CoA thiolase (KCT) is involved in fatty acid β oxidation[1]<.
- Biosynthetic thiolases like acetoacetyl-CoA thiolase (ACT) are involved in the thiolysis of acetoacetyl-CoA[2]<.
For Bacterial thiolase see Bacterial thiolase
3D Structures of Thiolase
Updated on 12-September-2016
References
- ↑ Sundaramoorthy R, Micossi E, Alphey MS, Germain V, Bryce JH, Smith SM, Leonard GA, Hunter WN. The crystal structure of a plant 3-ketoacyl-CoA thiolase reveals the potential for redox control of peroxisomal fatty acid beta-oxidation. J Mol Biol. 2006 Jun 2;359(2):347-57. Epub 2006 Mar 29. PMID:16630629 doi:http://dx.doi.org/10.1016/j.jmb.2006.03.032
- ↑ Soto G, Stritzler M, Lisi C, Alleva K, Pagano ME, Ardila F, Mozzicafreddo M, Cuccioloni M, Angeletti M, Ayub ND. Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. J Exp Bot. 2011 Nov;62(15):5699-711. doi: 10.1093/jxb/err287. Epub 2011 Sep 9. PMID:21908473 doi:http://dx.doi.org/10.1093/jxb/err287
