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1os9
From Proteopedia
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|PDB= 1os9 |SIZE=350|CAPTION= <scene name='initialview01'>1os9</scene>, resolution 1.85Å | |PDB= 1os9 |SIZE=350|CAPTION= <scene name='initialview01'>1os9</scene>, resolution 1.85Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span> |
|GENE= MMP12 OR HME ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= MMP12 OR HME ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1jk3|1JK3]], [[1os2|1OS2]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1os9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1os9 OCA], [http://www.ebi.ac.uk/pdbsum/1os9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1os9 RCSB]</span> | ||
}} | }} | ||
'''Binary enzyme-product complexes of human MMP12''' | '''Binary enzyme-product complexes of human MMP12''' | ||
| - | |||
| - | ==Disease== | ||
| - | Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Cardiomyopathy, familial hypertrophic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Muscular dystrophy, limb-girdle, type 2J OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Myopathy, early-onset, with fatal cardiomyopathy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Myopathy, proximal, with early respiratory muscle involvement OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Tibial muscular dystrophy, tardive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Mangani, S.]] | [[Category: Mangani, S.]] | ||
[[Category: Terni, B.]] | [[Category: Terni, B.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: ZN]] | ||
[[Category: complex (elastase/inhibitor)]] | [[Category: complex (elastase/inhibitor)]] | ||
[[Category: elastase]] | [[Category: elastase]] | ||
| Line 38: | Line 36: | ||
[[Category: mmp12]] | [[Category: mmp12]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:49:38 2008'' |
Revision as of 19:49, 30 March 2008
| |||||||
| , resolution 1.85Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | MMP12 OR HME (Homo sapiens) | ||||||
| Activity: | Macrophage elastase, with EC number 3.4.24.65 | ||||||
| Related: | 1JK3, 1OS2
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Binary enzyme-product complexes of human MMP12
About this Structure
1OS9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
X-ray structures of binary and ternary enzyme-product-inhibitor complexes of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, Angew Chem Int Ed Engl. 2003 Jun 16;42(23):2673-6. PMID:12813751
Page seeded by OCA on Sun Mar 30 22:49:38 2008
