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Thymidylate synthase

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Line 23: Line 23:
**[[1tis]] – TS – ''Enterobacteria'' phage T4<br />
**[[1tis]] – TS – ''Enterobacteria'' phage T4<br />
**[[1bsf]], [[1bko]], [[1bkp]], [[1bsp]] - BsTS - ''Bacillus subtilis''<br />
**[[1bsf]], [[1bko]], [[1bkp]], [[1bsp]] - BsTS - ''Bacillus subtilis''<br />
-
**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]]- hTS – human<br />
+
**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]], [[4up1]]- hTS – human<br />
**[[3n5g]], [[4kpw]] – hTS His-tag<br />
**[[3n5g]], [[4kpw]] – hTS His-tag<br />
**[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]], [[4jef]], [[4o1u]], [[4o1x]] – hTS (mutant)<br />
**[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]], [[4jef]], [[4o1u]], [[4o1x]] – hTS (mutant)<br />
Line 32: Line 32:
**[[3ge9]], [[4h0r]] - CgTS – ''Corynebacterium glutamicum''<br />
**[[3ge9]], [[4h0r]] - CgTS – ''Corynebacterium glutamicum''<br />
**[[4iqb]] – nTS – nematode<br />
**[[4iqb]] – nTS – nematode<br />
 +
**[[4xse]] - VvTS – Varicella-zoster virus<br />
*Thymidylate synthase binary complex
*Thymidylate synthase binary complex
Line 66: Line 67:
**[[4ein]] – mTS + substrate analog<br />
**[[4ein]] – mTS + substrate analog<br />
**[[3uwl]] – EfTS + 5-formyl tetrahydrofolate – ''Enterococcus faecalis''<br >
**[[3uwl]] – EfTS + 5-formyl tetrahydrofolate – ''Enterococcus faecalis''<br >
-
**[[4psg]] – TS + inhibitor – ''Caenorhabditis elegans''<br >
+
**[[4psg]] – nTS + inhibitor <br >
-
**[[4g9u]] – TS + UMP – ''Trichinella spiralis''<br />
+
**[[4g9u]], [[5by6]] – TS + UMP – ''Trichinella spiralis''<br />
**[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br />
**[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br />
**[[3fnn]] - CgTS + FAD <br />
**[[3fnn]] - CgTS + FAD <br />
**[[4h0u]] – CgTS + UMP<br />
**[[4h0u]] – CgTS + UMP<br />
**[[4irr]], [[4isw]] – nTS + UMP<br />
**[[4irr]], [[4isw]] – nTS + UMP<br />
 +
**[[4xsc]] - VvTS + d-Uridine derivative <br />
 +
**[[4xsd]] - VvTS + dUMP<br />
*Thymidylate synthase ternary complex
*Thymidylate synthase ternary complex
Line 134: Line 137:
**[[4gte]] – TmTS (mutant) + FAD + folate<br />
**[[4gte]] – TmTS (mutant) + FAD + folate<br />
**[[4gtb]] – TmTS + FAD + UMP + raltitrexed<br />
**[[4gtb]] – TmTS + FAD + UMP + raltitrexed<br />
 +
**[[5ioq]], [[5ior]] – TmTS + FAD + d-Uridine derivative<br />
 +
**[[5ios]], [[2iot]] – TmTS (mutant) + FAD + dUMP<br />
**[[3ge9]] - CgTS – ''Corynebacterium glutamicum''<br />
**[[3ge9]] - CgTS – ''Corynebacterium glutamicum''<br />
**[[3fnn]] - CgTS + FAD <br />
**[[3fnn]] - CgTS + FAD <br />
-
**[[3ah5]], [[3n3y]] - TS + FAD + UMP – ''Helicobacter pylori''
+
**[[3ah5]], [[3n3y]] - TS + FAD + UMP – ''Helicobacter pylori''<br />
 +
**[[4p5a]], [[5p5b]] – TS + FAD + dUMP derivative – ''Streptomyces cacaoi''<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:45, 14 September 2016

Thymidylate synthase complex with dUMP (stick model) (PDB entry 1tsv)

Drag the structure with the mouse to rotate

3D structures of thymidylate synthase

Updated on 14-September-2016

References

  1. ↑ Kaneda S, Nalbantoglu J, Takeishi K, Shimizu K, Gotoh O, Seno T, Ayusawa D. Structural and functional analysis of the human thymidylate synthase gene. J Biol Chem. 1990 Nov 25;265(33):20277-84. PMID:2243092
  2. ↑ Rahman L, Voeller D, Rahman M, Lipkowitz S, Allegra C, Barrett JC, Kaye FJ, Zajac-Kaye M. Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. Cancer Cell. 2004 Apr;5(4):341-51. PMID:15093541
  3. ↑ Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM. Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng. 1996 Jan;9(1):69-75. PMID:9053905
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