TIR domain-containing adapter protein
From Proteopedia
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<StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain complex with dithiothreitol (PDB code [[3ub2]])' scene=''> | <StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain complex with dithiothreitol (PDB code [[3ub2]])' scene=''> | ||
| - | '''TIR domain-containing adaptor protein''' (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: '''MyD88, MAL, TRIF, TRAM and SARM'''. The TIR domain, which is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response. | + | '''TIR domain-containing adaptor protein''' (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: '''MyD88, MAL, TRIF, TRAM and SARM'''. The TIR domain, which is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein<ref>PMID:17457343</ref>. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response. |
== Function == | == Function == | ||
Revision as of 09:54, 14 September 2016
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3D Structures of TIR domain-containing adaptor protein
Updated on 14-September-2016
References
- ↑ O'Neill LA, Bowie AG. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol. 2007 May;7(5):353-64. PMID:17457343 doi:http://dx.doi.org/nri2079
