5dex
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, phenyl-ACEPC== | |
| - | + | <StructureSection load='5dex' size='340' side='right' caption='[[5dex]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5dex]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DEX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5E0:5-[(2R)-2-AMINO-2-CARBOXYETHYL]-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC+ACID'>5E0</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ddn|5ddn]], [[5ddx|5ddx]], [[5de4|5de4]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dex OCA], [http://pdbe.org/5dex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dex RCSB], [http://www.ebi.ac.uk/pdbsum/5dex PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dex ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> [[http://www.uniprot.org/uniprot/NMDE1_RAT NMDE1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Conti, P]] | ||
| + | [[Category: Hansen, K B]] | ||
| + | [[Category: Mou, T C]] | ||
[[Category: Pinto, A]] | [[Category: Pinto, A]] | ||
| + | [[Category: Sprang, S R]] | ||
[[Category: Tamborini, L]] | [[Category: Tamborini, L]] | ||
| - | [[Category: | + | [[Category: Receptor]] |
| - | [[Category: | + | [[Category: Transport protein]] |
| - | + | ||
| - | + | ||
Revision as of 15:28, 14 September 2016
Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, phenyl-ACEPC
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