5dhq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor== | |
| - | + | <StructureSection load='5dhq' size='340' side='right' caption='[[5dhq]], [[Resolution|resolution]] 2.29Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5dhq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DHQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5AK:8-[(2-{[2-(3-BROMOPHENYL)ETHYL]AMINO}-2-OXOETHYL)SULFANYL]ADENOSINE'>5AK</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dhu|5dhu]], [[5dht|5dht]], [[5dhs|5dhs]], [[5dhr|5dhr]], [[5dhp|5dhp]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_kinase NAD(+) kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.23 2.7.1.23] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dhq OCA], [http://pdbe.org/5dhq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dhq RCSB], [http://www.ebi.ac.uk/pdbsum/5dhq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dhq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NADK1_LISMO NADK1_LISMO]] Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.[HAMAP-Rule:MF_00361]<ref>PMID:17686780</ref> <ref>PMID:22608967</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Assairi, L]] | ||
| + | [[Category: Gelin, M]] | ||
[[Category: Huteau, V]] | [[Category: Huteau, V]] | ||
[[Category: Labesse, G]] | [[Category: Labesse, G]] | ||
| - | [[Category: | + | [[Category: Paoletti, J]] |
[[Category: Pochet, S]] | [[Category: Pochet, S]] | ||
| - | [[Category: | + | [[Category: Tetrameric nad kinase]] |
| - | [[Category: | + | [[Category: Transferase]] |
Revision as of 15:28, 14 September 2016
Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with a novel inhibitor
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