5g3m
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor.== | |
| - | + | <StructureSection load='5g3m' size='340' side='right' caption='[[5g3m]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5g3m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G3M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9JH:4-BENZYLBENZAMIDE'>9JH</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g3n|5g3n]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g3m OCA], [http://pdbe.org/5g3m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g3m RCSB], [http://www.ebi.ac.uk/pdbsum/5g3m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g3m ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PA2GX_HUMAN PA2GX_HUMAN]] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bodin, C]] | ||
[[Category: Hallberg, K]] | [[Category: Hallberg, K]] | ||
| - | [[Category: Bodin, C]] | ||
[[Category: Sandmark, J]] | [[Category: Sandmark, J]] | ||
| + | [[Category: Cardiovascular disease]] | ||
| + | [[Category: Fragment]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Spla2]] | ||
Revision as of 15:31, 14 September 2016
Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor.
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