5g3n
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor.== | |
| - | + | <StructureSection load='5g3n' size='340' side='right' caption='[[5g3n]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5g3n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G3N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=X28:3-(5-BENZYL-2-CARBAMOYLBIPHENYL-3-YL)PROPANOIC+ACID'>X28</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g3m|5g3m]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g3n OCA], [http://pdbe.org/5g3n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g3n RCSB], [http://www.ebi.ac.uk/pdbsum/5g3n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g3n ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PA2GA_HUMAN PA2GA_HUMAN]] Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bodin, C]] | ||
[[Category: Hallberg, K]] | [[Category: Hallberg, K]] | ||
| - | [[Category: Bodin, C]] | ||
[[Category: Sandmark, J]] | [[Category: Sandmark, J]] | ||
| + | [[Category: Cardiovascular disease]] | ||
| + | [[Category: Fragment]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Secreted phospholipase a2]] | ||
| + | [[Category: Spla2]] | ||
Revision as of 15:31, 14 September 2016
Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor.
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