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5gip

From Proteopedia

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m (Protected "5gip" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5gip is ON HOLD until Paper Publication
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==Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates==
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<StructureSection load='5gip' size='340' side='right' caption='[[5gip]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5gip]] is a 20 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GIP FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gin|5gin]], [[5gio|5gio]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gip OCA], [http://pdbe.org/5gip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gip RCSB], [http://www.ebi.ac.uk/pdbsum/5gip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gip ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/A0A0E3JUC9_SULSF A0A0E3JUC9_SULSF]] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.[HAMAP-Rule:MF_00351] [[http://www.uniprot.org/uniprot/A0A0E3JZF7_SULSF A0A0E3JZF7_SULSF]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.[HAMAP-Rule:MF_00326]
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__TOC__
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</StructureSection>
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[[Category: Lin, J]]
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[[Category: Yang, Z]]
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[[Category: Ye, K]]
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[[Category: 2'-o-methylation]]
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[[Category: Guide rna]]
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[[Category: Rnp]]
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[[Category: Transferase-rna complex]]

Revision as of 15:31, 14 September 2016

Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates

5gip, resolution 3.13Å

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