5ljy
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of hantavirus envelope glycoprotein Gc in complex with scFv A5== | |
| - | + | <StructureSection load='5ljy' size='340' side='right' caption='[[5ljy]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ljy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LJY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ljy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ljy OCA], [http://pdbe.org/5ljy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ljy RCSB], [http://www.ebi.ac.uk/pdbsum/5ljy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ljy ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GP_HANTV GP_HANTV]] Glycoprotein N and Glycoprotein C interact with each. other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Glycoprotein N contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).<ref>PMID:11886265</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Guardado-Calvo, P]] | [[Category: Guardado-Calvo, P]] | ||
| - | [[Category: Jeffers, S | + | [[Category: Jeffers, S A]] |
| + | [[Category: Rey, F A]] | ||
[[Category: Stettner, E]] | [[Category: Stettner, E]] | ||
| - | [[Category: | + | [[Category: Glycoprotein]] |
| + | [[Category: Hantavirus]] | ||
| + | [[Category: Viral fusion]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 15:36, 14 September 2016
Structure of hantavirus envelope glycoprotein Gc in complex with scFv A5
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