5ljz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of hantavirus envelope glycoprotein Gc in postfusion conformation== | |
| - | + | <StructureSection load='5ljz' size='340' side='right' caption='[[5ljz]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ljz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LJZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ljz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ljz OCA], [http://pdbe.org/5ljz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ljz RCSB], [http://www.ebi.ac.uk/pdbsum/5ljz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ljz ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GP_HANTV GP_HANTV]] Glycoprotein N and Glycoprotein C interact with each. other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Glycoprotein N contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).<ref>PMID:11886265</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Guardado-Calvo, P]] | [[Category: Guardado-Calvo, P]] | ||
| - | [[Category: Rey, F | + | [[Category: Rey, F A]] |
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Hantavirus]] | ||
| + | [[Category: Viral fusion]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 15:36, 14 September 2016
Structure of hantavirus envelope glycoprotein Gc in postfusion conformation
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