Topoisomerase binding protein

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<StructureSection load='3ueo' size='350' side='right' caption='Structure of human topoisomerase binding protein BRCT 4-5 domain tetramer (gray, green, pink, yellow) complex with phospho-peptide (magenta and cyan) (PDB entry [[3ueo]])' scene=''>
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<StructureSection load='3ueo' size='350' side='right' caption='Structure of human topoisomerase binding protein BRCT 4-5 domain tetramer (gray, pink) complex with phospho-peptide (cyan) (PDB entry [[3ueo]])' scene=''>
'''Topoisomerase binding protein''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks. TopBP1 contains BRCT domains which are ca. 100 amino acid long tandem repeat which bind phosphor-peptides.
'''Topoisomerase binding protein''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks. TopBP1 contains BRCT domains which are ca. 100 amino acid long tandem repeat which bind phosphor-peptides.

Revision as of 09:46, 18 September 2016

Structure of human topoisomerase binding protein BRCT 4-5 domain tetramer (gray, pink) complex with phospho-peptide (cyan) (PDB entry 3ueo)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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