Topoisomerase binding protein
From Proteopedia
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<StructureSection load='3ueo' size='350' side='right' caption='Structure of human topoisomerase binding protein BRCT 4-5 domain tetramer (gray, pink) complex with phospho-peptide (cyan) (PDB entry [[3ueo]])' scene=''> | <StructureSection load='3ueo' size='350' side='right' caption='Structure of human topoisomerase binding protein BRCT 4-5 domain tetramer (gray, pink) complex with phospho-peptide (cyan) (PDB entry [[3ueo]])' scene=''> | ||
| - | '''Topoisomerase binding protein''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks. TopBP1 contains BRCT domains which are ca. 100 amino acid long tandem repeat which bind phosphor-peptides. | + | '''Topoisomerase binding protein''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks<ref>PMID:9461304</ref>. TopBP1 contains BRCT domains which are ca. 100 amino acid long tandem repeat which bind phosphor-peptides. |
==3D structures of topoisomerase binding protein== | ==3D structures of topoisomerase binding protein== | ||
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[[3al2]] – hTopBP1 BRCT 7-8 domains <br /> | [[3al2]] – hTopBP1 BRCT 7-8 domains <br /> | ||
[[3al3]] – hTopBP1 BRCT 7-8 domains + Fanconi anemia group J protein peptide<br /> | [[3al3]] – hTopBP1 BRCT 7-8 domains + Fanconi anemia group J protein peptide<br /> | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Revision as of 09:49, 18 September 2016
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