Transcription initiation factor

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* '''TFIID''' recognizes the promoter sequence on the DNA.<br />
* '''TFIID''' recognizes the promoter sequence on the DNA.<br />
* '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br />
* '''TFIIE''' both subunits are are essential to form a preinitiation complex.<ref>PMID:1956398</ref><br />
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* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.
+
* '''TFIIF''' binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.<b />
 +
* '''TF RRN3''' initiates transcription by RNA polymerase I in yeast.<ref>PMID:8670901</ref><br />
</StructureSection>
</StructureSection>

Revision as of 10:03, 20 September 2016

Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry 1vol)

Drag the structure with the mouse to rotate

3D structures of transcription initiation factors

Updated on 20-September-2016

References

  1. Roeder RG. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem Sci. 1996 Sep;21(9):327-35. PMID:8870495
  2. Kuhlman TC, Cho H, Reinberg D, Hernandez N. The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter. Mol Cell Biol. 1999 Mar;19(3):2130-41. PMID:10022900
  3. Ha I, Lane WS, Reinberg D. Cloning of a human gene encoding the general transcription initiation factor IIB. Nature. 1991 Aug 22;352(6337):689-95. PMID:1876184 doi:http://dx.doi.org/10.1038/352689a0
  4. Peterson MG, Inostroza J, Maxon ME, Flores O, Admon A, Reinberg D, Tjian R. Structure and functional properties of human general transcription factor IIE. Nature. 1991 Dec 5;354(6352):369-73. PMID:1956398 doi:http://dx.doi.org/10.1038/354369a0
  5. Yamamoto RT, Nogi Y, Dodd JA, Nomura M. RRN3 gene of Saccharomyces cerevisiae encodes an essential RNA polymerase I transcription factor which interacts with the polymerase independently of DNA template. EMBO J. 1996 Aug 1;15(15):3964-73. PMID:8670901

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