Transducin
From Proteopedia
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== Function == | == Function == | ||
| - | '''Transducin''' (TDN) is a heterotrimeric G protein containing 3 chains: α, β and γ which are organized in two subunits: α and βγ. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the GDP bound to its α subunit is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TND preventing its reassociation with the α subunit. | + | '''Transducin''' (TDN) is a heterotrimeric G protein containing 3 chains: α, β and γ which are organized in two subunits: α and βγ<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the GDP bound to its α subunit is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TND preventing its reassociation with the α subunit. |
== Disease == | == Disease == | ||
Revision as of 10:41, 20 September 2016
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3D structures of transducin
Updated on 20-September-2016
References
- ↑ Lerea CL, Bunt-Milam AH, Hurley JB. Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina. Neuron. 1989 Sep;3(3):367-76. PMID:2534964
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
