1oxb
From Proteopedia
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|PDB= 1oxb |SIZE=350|CAPTION= <scene name='initialview01'>1oxb</scene>, resolution 2.30Å | |PDB= 1oxb |SIZE=350|CAPTION= <scene name='initialview01'>1oxb</scene>, resolution 2.30Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= YPD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), SLN1 OR YPD2 OR YIL147C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | |GENE= YPD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), SLN1 OR YPD2 OR YIL147C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1qsp|1QSP]], [[1oxk|1OXK]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oxb OCA], [http://www.ebi.ac.uk/pdbsum/1oxb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oxb RCSB]</span> | ||
}} | }} | ||
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[[Category: West, A H.]] | [[Category: West, A H.]] | ||
[[Category: Xu, Q.]] | [[Category: Xu, Q.]] | ||
| - | [[Category: SO4]] | ||
[[Category: histidine-containing phosphotransfer protein]] | [[Category: histidine-containing phosphotransfer protein]] | ||
[[Category: hpt domain]] | [[Category: hpt domain]] | ||
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[[Category: ypd1p]] | [[Category: ypd1p]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:51:43 2008'' |
Revision as of 19:51, 30 March 2008
| |||||||
| , resolution 2.30Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | YPD1 (Saccharomyces cerevisiae), SLN1 OR YPD2 OR YIL147C (Saccharomyces cerevisiae) | ||||||
| Related: | 1QSP, 1OXK
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)
Overview
In Saccharomyces cerevisiae, a branched multistep phosphorelay signaling pathway regulates cellular adaptation to hyperosmotic stress. YPD1 functions as a histidine-phosphorylated protein intermediate required for phosphoryl group transfer from a membrane-bound sensor histidine kinase (SLN1) to two distinct response regulator proteins (SSK1 and SKN7). These four proteins are evolutionarily related to the well-characterized "two-component" regulatory proteins from bacteria. Although structural information is available for many two-component signaling proteins, there are very few examples of complexes between interacting phosphorelay partners. Here we report the first crystal structure of a prototypical monomeric histidine-containing phosphotransfer (HPt) protein YPD1 in complex with its upstream phosphodonor, the response regulator domain associated with SLN1.
About this Structure
1OXB is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
The yeast YPD1/SLN1 complex: insights into molecular recognition in two-component signaling systems., Xu Q, Porter SW, West AH, Structure. 2003 Dec;11(12):1569-81. PMID:14656441
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