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5dod

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'''Unreleased structure'''
 
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The entry 5dod is ON HOLD until Paper Publication
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==Human A20 OTU domain with I325N and alkylated C103 to 2.5A resolution==
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<StructureSection load='5dod' size='340' side='right' caption='[[5dod]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors: Langley, D.B., Christ, D., Grey, S.T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5dod]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DOD FirstGlance]. <br>
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Description: Human A20 OTU domain with I325N and alkylated C103 to 2.5A resolution
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zrh|4zrh]]</td></tr>
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[[Category: Langley, D.B]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dod OCA], [http://pdbe.org/5dod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dod RCSB], [http://www.ebi.ac.uk/pdbsum/5dod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dod ProSAT]</span></td></tr>
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[[Category: Grey, S.T]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TNAP3_HUMAN TNAP3_HUMAN]] Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system.<ref>PMID:8692885</ref> <ref>PMID:9299557</ref> <ref>PMID:9882303</ref> <ref>PMID:14748687</ref> <ref>PMID:15258597</ref> <ref>PMID:16684768</ref> <ref>PMID:18952128</ref> <ref>PMID:19494296</ref> <ref>PMID:22099304</ref> <ref>PMID:17961127</ref> <ref>PMID:18164316</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Christ, D]]
[[Category: Christ, D]]
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[[Category: Grey, S T]]
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[[Category: Langley, D B]]
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[[Category: Hydrolase]]
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[[Category: Ubiquitin protease]]

Revision as of 13:46, 21 September 2016

Human A20 OTU domain with I325N and alkylated C103 to 2.5A resolution

5dod, resolution 2.50Å

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