5lp6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Tubulin-Stathmin-TTL-Thiocolchicine Complex== | |
| - | + | <StructureSection load='5lp6' size='340' side='right' caption='[[5lp6]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lp6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LP6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=71P:~{N}-[(7~{R})-1,2,3-TRIMETHOXY-10-METHYLSULFANYL-9-OXIDANYLIDENE-6,7-DIHYDRO-5~{H}-BENZO[A]HEPTALEN-7-YL]ETHANAMIDE'>71P</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lp6 OCA], [http://pdbe.org/5lp6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lp6 RCSB], [http://www.ebi.ac.uk/pdbsum/5lp6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lp6 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Aliverti, A]] | ||
[[Category: Cappelletti, G]] | [[Category: Cappelletti, G]] | ||
[[Category: Casagrande, F]] | [[Category: Casagrande, F]] | ||
| - | [[Category: | + | [[Category: Christodoulou, M]] |
| - | [[Category: | + | [[Category: Marangon, J]] |
| + | [[Category: Passarella, D]] | ||
[[Category: Ricagno, S]] | [[Category: Ricagno, S]] | ||
| - | [[Category: | + | [[Category: Tiana, G]] |
| - | [[Category: | + | [[Category: Via, L Dalla]] |
| + | [[Category: Microtubule]] | ||
| + | [[Category: Structural protein]] | ||
| + | [[Category: Thiocolchicine]] | ||
| + | [[Category: Tubulin]] | ||
| + | [[Category: Tubulin-tyrosine ligase]] | ||
Revision as of 13:59, 21 September 2016
Crystal structure of Tubulin-Stathmin-TTL-Thiocolchicine Complex
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