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Trypanothione reductase
From Proteopedia
(Difference between revisions)
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| - | {{STRUCTURE_1bzl| PDB=1bzl | SIZE=400| SCENE= |right|CAPTION=Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione, [[1bzl]] }} | ||
| - | < | + | <StructureSection load='4adw' size='340' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene=''> |
| - | + | == Function == | |
| - | + | '''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. | |
| - | + | ||
| - | + | == Relevance == | |
| - | '''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor. TTR is found only in parasitic protozoa, hence its inhibitors are used as effective drugs against diseases caused by the parasites Trypanosoma and Leishmania. | + | TTR is found only in parasitic protozoa, hence its inhibitors are used as effective drugs against diseases like Chagas Disease caused by the parasites Trypanosoma and Leishmania<ref>PMID:12769656</ref>. |
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| + | == Structural highlights == | ||
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| + | </StructureSection> | ||
==3D structures of trypanothione reductase== | ==3D structures of trypanothione reductase== | ||
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**[[2w0h]], [[2x50]] - LiTTR + NADPH + metal ion<br /> | **[[2w0h]], [[2x50]] - LiTTR + NADPH + metal ion<br /> | ||
**[[2yau]] - LiTTR + NADPH + inhibitor<br /> | **[[2yau]] - LiTTR + NADPH + inhibitor<br /> | ||
| - | **[[2wow]] - TbTTR + NADPH + TPT<BR /> | + | **[[2wow]] - TbTTR + NADPH + TPT + inhibitor<BR /> |
**[[4adw]] - LiTTR + NADPH + TPT<br /> | **[[4adw]] - LiTTR + NADPH + TPT<br /> | ||
**[[4apn]] - LiTTR + NADPH + inhibitor<br /> | **[[4apn]] - LiTTR + NADPH + inhibitor<br /> | ||
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**[[1typ]] – CfTTR + NADP + TPT<BR /> | **[[1typ]] – CfTTR + NADP + TPT<BR /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Revision as of 10:36, 26 September 2016
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3D structures of trypanothione reductase
Updated on 26-September-2016
References
- ↑ Rivarola HW, Paglini-Oliva PA. Trypanosoma cruzi trypanothione reductase inhibitors: phenothiazines and related compounds modify experimental Chagas' disease evolution. Curr Drug Targets Cardiovasc Haematol Disord. 2002 Jun;2(1):43-52. PMID:12769656
