Tryptophan synthase
From Proteopedia
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<StructureSection load='1wbj' size='340' side='right' caption='Tryptophan synthase α subunit (grey) and β subunit (green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) [[1wbj]]' scene=''> | <StructureSection load='1wbj' size='340' side='right' caption='Tryptophan synthase α subunit (grey) and β subunit (green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) [[1wbj]]' scene=''> | ||
== Function == | == Function == | ||
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**[[1xcf]] - EcTrpS α subunit (mutant)<br /> | **[[1xcf]] - EcTrpS α subunit (mutant)<br /> | ||
**[[2ekc]] - TrpS α subunit – ''Aquifex aeolicus''<br /> | **[[2ekc]] - TrpS α subunit – ''Aquifex aeolicus''<br /> | ||
| + | **[[5kmy]], [[5k9x]] - TrpS α subunit – ''Legionella pneumophila''<br /> | ||
*Tryptophan synthase α binary complex | *Tryptophan synthase α binary complex | ||
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**[[1kfj]] - StTrpS α + β + pyridoxal-serine-monophsphate<br /> | **[[1kfj]] - StTrpS α + β + pyridoxal-serine-monophsphate<br /> | ||
**[[2j9y]] - StTrpS α + β (mutant) + enoic acid derivative<br /> | **[[2j9y]] - StTrpS α + β (mutant) + enoic acid derivative<br /> | ||
| - | **[[3pr2]] | + | **[[3pr2]], [[4hn4]], [[4hpj]], [[4hpx]], [[4ht3]], [[4kkx]] - StTrpS α + β + inhibitor<br /> |
| - | + | **[[5kzm]] - TrpS α + β + PLP derivative – ''Francisella tularensis''<br /> | |
| + | **[[5kin]] - TrpS α + β + PLP derivative – ''Streptococcus pneumoniae''<br /> | ||
| + | **[[5e0k]] - PfTrpS α + β + PLP derivative <br /> | ||
*Tryptophan synthase α+β ternary complex with PLP and inhibitor | *Tryptophan synthase α+β ternary complex with PLP and inhibitor | ||
| - | **[[1a50]], [[1cw2]], [[1c9d]], [[1cx9]], [[1c8v]], [[1c29]], [[2cle]], [[2clh]], [[2cli]], [[2clk]], [[2cll]], [[2clm]], [[2clo]], [[2clf]] - StTrpS α + β + inhibitor + PLP<br /> | + | **[[1a50]], [[1cw2]], [[1c9d]], [[1cx9]], [[1c8v]], [[1c29]], [[2cle]], [[2clh]], [[2cli]], [[2clk]], [[2cll]], [[2clm]], [[2clo]], [[2clf]], [[5bw6]], [[4zqc]], [[4y6g]], [[4xug]], [[4wx2]] - StTrpS α + β + inhibitor + PLP<br /> |
| + | **[[5cgq]] - StTrpS α + β + inhibitor + PLP + Trp<br /> | ||
**[[1fuy]] - StTrpS α + β (mutant) + inhibitor + PLP<br /> | **[[1fuy]] - StTrpS α + β (mutant) + inhibitor + PLP<br /> | ||
Revision as of 09:24, 27 September 2016
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3D structures of tryptophan synthase
Updated on 27-September-2016
References
- ↑ Miles EW. Tryptophan synthase: a multienzyme complex with an intramolecular tunnel. Chem Rec. 2001;1(2):140-51. PMID:11893063
- ↑ Shen H, Yang Y, Wang F, Zhang Y, Ye N, Xu S, Wang H. Characterization of the putative tryptophan synthase beta-subunit from Mycobacterium tuberculosis. Acta Biochim Biophys Sin (Shanghai). 2009 May;41(5):379-88. PMID:19430702
- ↑ Kulik V, Hartmann E, Weyand M, Frey M, Gierl A, Niks D, Dunn MF, Schlichting I. On the structural basis of the catalytic mechanism and the regulation of the alpha subunit of tryptophan synthase from Salmonella typhimurium and BX1 from maize, two evolutionarily related enzymes. J Mol Biol. 2005 Sep 23;352(3):608-20. PMID:16120446 doi:10.1016/j.jmb.2005.07.014
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