Tubulin

From Proteopedia

Revision as of 06:37, 28 September 2016

3D Structures of Tubulin

Updated on 28-September-2016 {{#tree:id=OrganizedByTopic|openlevels=0|

• α-tubulin

• • 2bto – PdTUBA+thioredoxin 1 – Prosthecobacter dejongeii
    
  • 2e4h – hTUBA C terminal + restin CAP-Gly domain 2 – human
    

• α-tubulin + β-tubulin

• • 1jff - bTUBA+bTUBB - bovine
    
  • 3j6f - pTUBA+pTUBB – pig - Cryo EM
    
  • 3j6e - pTUBA+pTUBB +GMPCPP – Cryo EM
    
  • 3j7i - pTUBA+pTUBB +GTP – Cryo EM
    
  • 1tub - pTUBA+pTUBB – electron diffraction
    
  • 2btq – PdTUBA+PdTUBB
    

• α-tubulin + β-tubulin complexes with stathmin

• • 3hkb, 3hkc, 3hkd, 3hke, 3n2g, 3n2k, 3ryc, 3ryf, 3ryh, 3ryi, 4eb6 – sTUBA+sTUBB+stathmin-4 – sheep
    
  • 4f61 - sTUBA+sTUBB+stathmin-like protein R4
    
  • 3ut5 - sTUBA+sTUBB+stathmin-4 + vinca peptide
    
  • 4eb6 - sTUBA+sTUBB+stathmin-4
    
  • 4x1i, 4x1k, 4x1y, 4x20 - sTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + dolastatin + colchicine
    
  • 5eyp - sTUBA+sTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + colchicine
    

4f6r - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein

• • 5lp6 – bTUBA1B +bTUBB2B +stathmin-4 + protein
    
  • 3du7, 3e22, 1z2b, 1sa0, 1sa1, 1ffx – bTUBA1C+bTUBB2B+stathmin-4
    
  • 4o2a, 4iij, 4i55 - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase
    
  • 4wbn - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative
    
  • 5la6 - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + pironetin
    
  • 5bmv - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + vinblastine
    
  • 5jh7 - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + eribulin
    
  • 5la6 - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ATP derivative + benzodioxol derivative
    
  • 5iyz, 5j2t, 5j2u, 4tv9, 4yj2, 4yj3, 2xrp – bTUBAB1 +bTUBBB2 +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + auristatin anti-mitotics
    
  • 4o2b - bTUBA+bTUBB+stathmin-4 + TUB-Tyr ligase + colchicine
    
  • 4tuy, 4o4h, 4o4i, 4o4j, 4o4l, 4i50, 4i4t, 4tv8,
  • 4zhq, 4zi7, 4zol – pTUBAB1 +pTUBBB2 +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ATP derivative + valinamide derivative
    
  • 4ihj - bTUBA+bTUBB+stathmin-4 + tubulin Tyr-ligase + ADP
    

• α-tubulin + β-tubulin complex with kinesin

• • 4lnu - sTUBA+sTUBB + ankyrin repeat protein + GDP + GTP + kinesin heavy chain
    
  • 2wbe – bTUBA1D+bTUBB2B+kinesin+AMPPNP
    
  • 3dco - bTUBA+bTUBB+kinesin-like NOD
    
  • 4ck5, 4ck6, 4ck7 - bTUBA+bTUBB+kinesin-like KIF11 motor domain
    
  • 5hnw, 5hnx, 5hny, 5hnz – bTUBAB1 +bTUBBB2 +kinesin-14 + GDP + GTP + taxol
    
  • [[3edl}} - bTUBA1D+bTUBB2B+kinesin motor domain
    
  • 4hna - bTUBA+bTUBB + kinesin heavy chain + ankyrin repeat protein
    
  • 4uxo, 4uxp, 4uxr, 4uxs, 4uxy - bTUBA+bTUBB + kinesin motor domain + GDP + GTP + taxol – Cryo EM
    
  • 4uxt, 4uy0 - bTUBA+bTUBB + kinesin heavy chain + GDP + GTP + taxol – Cryo EM
    
  • 3j2u - bTUBA+bTUBB+kinesin-like KLP10A head domain
    
  • 2p4n - hTUBA+hTUBB+kinesin heavy chain
    
  • 2hxf - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP
    
  • 3j6h - pTUBA+pTUBB +GMPCPP + kinesin heavy chain – Cryo EM
    
  • 3j8x - pTUBA+pTUBB +GDP + GTP + kinesin heavy chain – Cryo EM
    
  • 3j8y - pTUBA+pTUBB +GDP + GTP + ATP + kinesin heavy chain – Cryo EM
    
  • 2hxh - pTUBA+pTUBB+kinesin-like KIF1A+ADP
    
  • 1ia0 - pTUBA+pTUBB+kinesin-like KIF1A+ATP
    
  • 4aqv, 4aqw - bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM
    
  • 4atx - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM
    

• α-tubulin + β-tubulin other complexes

• • 4drx - sTUBA+sTUBB + ankyrin repeat protein
    
  • 1tvk - bTUBA+bTUBB+GDP+GTP+Epothilone A – electron crystallography
    
  • 3iz0 - bTUBA+bTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy
    
  • 3j1t, 3j1u - bTUBA+bTUBB+ dynein
    
  • 3j6p - pTUBA+pTUBB +GTP + GDP + taxol + dynein heavy chain – Cryo EM
    
  • 3j6g - pTUBA+pTUBB +GTP + GDP + taxol – Cryo EM
    
  • 5kmg - pTUBA+pTUBB + protein regulator + GTP + GDP – Cryo EM
    
  • 4abo - pTUBA+pTUBB+ microtubule integrity protein MAL3
    
  • 4atu - bTUBA1D+bTUBB2B+doublecortin – Cryo EM
    
  • 4ffb, 4u3j - TUBA+TUBB (mutant) + protein STU2 – yeast
    

• γ-tubulin

• • 3cb2 – hTUBG1+GDP
    
  • 1z5v - hTUBG1+GTPgS
    
  • 1z5w - hTUBG1+GTP
    
  • 3rip – hTUBG4
    

• FtsZ

• • 2vxy, 2vam – BsFtsZ - Bacillus subtilis
    
  • 2ve8 – PaFtsZ gamma domain – Pseudomonas aeruginosa
    
  • 2r6r– AaFtsZ - Aquifex aeolicus
    
  • 1w59, 1fsz – MjFtsZ - Methancaldococcus jannaschii
    
  • 1w5e, 1w5f – MjFtsZ (mutant)
    
  • 3v3t – FtsZ (mutant) – Clostridium botulinum
    
  • 3zid – FtsZ – Methanosaeta thermophila
    
  • 3vo9, 3vpa - SaFtsZ – Staphylococcus aureus
    
  • 3wgj, 3wgk – SaFtsZ (mutant)
    

• FtsZ complexes

• • 2rhh, 2rhj – BsFtsZ+SO4
    
  • 2rhl - BsFtsZ+GDP
    
  • 2rho - BsFtsZ+GDP+GTP-gamma-S
    
  • 4u39 – BsFtsZ + cell division factor
    
  • 2ve9 - PaFtsZ gamma domain+DNA
    
  • 2vaw – PaFtsZ+GDP
    
  • 1ofu - PaFtsZ+SULA
    
  • 2r75 - AaFtsZ+8-morpholino-GTP
    
  • 2q1x, 1rq2 - MtFtsZ+citrate – Mycobacterium tuberculosis
    
  • 2q1y, 1rlu - MtFtsZ+GTP-gamma-S
    
  • 1rq7, 4kwe - MtFtsZ+GDP
    
  • 2vap – MjFtsZ+GDP
    
  • 1w58 - MjFtsZ+GMPCPP
    
  • 1w5a - MjFtsZ+MgGTP
    
  • 1w5b - MjFtsZ+GTP
    
  • 4b45 – HvFtsZ + GTP-γS – Haloferax volcanii
    
  • 3vo8, 3voa - SaFtsZ + GDP
    
  • 3wgl – SaFtsZ (mutant) + GDP
    
  • 3wgn – SaFtsZ + GTP-γS
    
  • 3wgm – SaFtsZ (mutant) + GTP
    
  • 3vob - SaFtsZ + GDP + benzamide derivative
    
  • 4dxd - SaFtsZ + antibiotic
    
  • 4b46 - HvFtsZ + GDP
    
  • 4m8i - SeFtsZ + GDP – Staphylococcus epidermitis
    

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References

1. ↑ Moritz M, Agard DA. Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol. 2001 Apr;11(2):174-81. PMID:11297925
2. ↑ Arjes HA, Lai B, Emelue E, Steinbach A, Levin PA. Mutations in the bacterial cell division protein FtsZ highlight the role of GTP binding and longitudinal subunit interactions in assembly and function. BMC Microbiol. 2015 Oct 13;15:209. doi: 10.1186/s12866-015-0544-z. PMID:26463348 doi:http://dx.doi.org/10.1186/s12866-015-0544-z
3. ↑ Giarnieri E, De Francesco GP, Carico E, Midiri G, Amanti C, Giacomelli L, Tucci G, Gidaro S, Stroppa I, Gidaro G, Giovagnoli MR. Alpha- and beta-tubulin expression in rectal cancer development. Anticancer Res. 2005 Sep-Oct;25(5):3237-41. PMID:16101133
4. ↑ Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phan-Dinh-Tuy F, Kong XP, Bomont P, Castelnau-Ptakhine L, Odent S, Loget P, Kossorotoff M, Snoeck I, Plessis G, Parent P, Beldjord C, Cardoso C, Represa A, Flint J, Keays DA, Cowan NJ, Chelly J. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet. 2009 Jun;41(6):746-52. doi: 10.1038/ng.380. Epub 2009 May 24. PMID:19465910 doi:http://dx.doi.org/10.1038/ng.380