Tubulin tyrosine ligase

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<StructureSection load='3tin' size='340' side='right' caption='Tubulin tyrosine ligase complex with ADP and Mg+2 ions (PDB code [[3tin]])' scene=''>
<StructureSection load='3tin' size='340' side='right' caption='Tubulin tyrosine ligase complex with ADP and Mg+2 ions (PDB code [[3tin]])' scene=''>
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'''Tubulin tyrosine ligase''' (TTL) adds tyrosine in an ATP-dependent reaction to the C-terminal of a detyrosinated a-tubulin. The detyrosination of a-tubulin is a posttranslational modification which exposes glutamate in the new tubulin C-terminal. The detyrosinated a-tubulin forms Glu-microtubules.
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'''Tubulin tyrosine ligase''' (TTL) adds tyrosine in an ATP-dependent reaction to the C-terminal of a detyrosinated a-tubulin. The detyrosination of α-tubulin is a posttranslational modification which exposes glutamate in the new tubulin C-terminal. The detyrosinated α-tubulin forms Glu-microtubules<ref>PMID:10842328</ref>.
== Function ==
== Function ==
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== Disease ==
== Disease ==
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Mutated TTL causes morphogenic abnormalities and cancer.
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Mutated TTL causes morphogenic abnormalities and cancer. There is a loss of TTL activity during tumor growth<ref>PMID:9405300</ref>.
== Relevance ==
== Relevance ==

Revision as of 06:54, 28 September 2016

Tubulin tyrosine ligase complex with ADP and Mg+2 ions (PDB code 3tin)

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3D Structures of tubulin tyrosine ligase

Updated on 28-September-2016


3tig – fTTL - frog
3tii – fTTL + phosphomethylphosphonic acid adenylate
3tin – fTTL + ADP
4iij – cTTL + rSTM + tubulin + GTP + GDP - chicken
4ihj – cTTL + rSTM + tubulin + GTP + GDP + ADP
4wbn – cTTL + rSTM + tubulin + GTP + GDP + phosphomethylphosphonic acid adenylate
4o2a – cTTL + rSTM + tubulin + GTP + GDP + ADP + inhibitor
4i4t – cTTL + rSTM + tubulin + GTP + GDP + zampanolide
4i50 – cTTL + rSTM + tubulin + GTP + GDP + epothilone
4o4l, 4tuy, 4tv8, 4yj2, 4yj3 – cTTL + rSTM + tubulin + GTP + GDP + anti-cancer drugs
4i55 – cTTL + rSTM + tubulin + GTP + GDP + phosphomethylphosphonic acid adenylate
4o2b – cTTL + rSTM + tubulin + GTP + GDP + phosphomethylphosphonic acid adenylate + anti-gout drug
4o4h, 4o4j, 4o4i – cTTL + rSTM + tubulin + GTP + GDP + phosphomethylphosphonic acid adenylate + anti-cancer drug

References

  1. ↑ Idriss HT. Phosphorylation of tubulin tyrosine ligase: a potential mechanism for regulation of alpha-tubulin tyrosination. Cell Motil Cytoskeleton. 2000 May;46(1):1-5. PMID:10842328 doi:<1::AID-CM1>3.0.CO;2-6 http://dx.doi.org/10.1002/(SICI)1097-0169(200005)46:1<1::AID-CM1>3.0.CO;2-6
  2. ↑ Lafanechere L, Courtay-Cahen C, Kawakami T, Jacrot M, Rudiger M, Wehland J, Job D, Margolis RL. Suppression of tubulin tyrosine ligase during tumor growth. J Cell Sci. 1998 Jan;111 ( Pt 2):171-81. PMID:9405300

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Michal Harel, Joel L. Sussman, Alexander Berchansky

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