Tumor necrosis factor
From Proteopedia
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<StructureSection load='2az5' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene=''> | <StructureSection load='2az5' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene=''> | ||
| + | == Function == | ||
| + | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | ||
| - | + | == Relevance == | |
| + | TNF is studied as both a target and a therapeutic in malignant diseases<ref>PMID:19343034</ref>. | ||
</StructureSection> | </StructureSection> | ||
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**[[2vfj]] – hTNF ovarian tumor domain <BR /> | **[[2vfj]] – hTNF ovarian tumor domain <BR /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:29, 28 September 2016
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3D Structures of tumor necrosis factor
Updated on 28-September-2016
References
- ↑ Baud V, Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 2001 Sep;11(9):372-7. PMID:11514191
- ↑ Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009 May;9(5):361-71. doi: 10.1038/nrc2628. Epub 2009 Apr 3. PMID:19343034 doi:http://dx.doi.org/10.1038/nrc2628
