Tumor necrosis factor
From Proteopedia
(Difference between revisions)
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<StructureSection load='2az5' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene=''> | <StructureSection load='2az5' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | + | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). |
== Relevance == | == Relevance == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *TNF | + | *TNF α |
**[[1tnf]] – hTNF – human <BR /> | **[[1tnf]] – hTNF – human <BR /> | ||
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**[[4twt]] – hTNF + peptide <BR /> | **[[4twt]] – hTNF + peptide <BR /> | ||
| - | *TNF | + | *TNF β |
**[[1tnr]] – hTNF + TNF receptor p55 <BR /> | **[[1tnr]] – hTNF + TNF receptor p55 <BR /> | ||
Revision as of 08:47, 28 September 2016
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3D Structures of tumor necrosis factor
Updated on 28-September-2016
References
- ↑ Baud V, Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 2001 Sep;11(9):372-7. PMID:11514191
- ↑ Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009 May;9(5):361-71. doi: 10.1038/nrc2628. Epub 2009 Apr 3. PMID:19343034 doi:http://dx.doi.org/10.1038/nrc2628
