1p51

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|PDB= 1p51 |SIZE=350|CAPTION= <scene name='initialview01'>1p51</scene>, resolution 2.50&Aring;
|PDB= 1p51 |SIZE=350|CAPTION= <scene name='initialview01'>1p51</scene>, resolution 2.50&Aring;
|SITE=
|SITE=
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|LIGAND=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= HUP OR HANA OR ASR3935 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1167 Anabaena sp.])
|GENE= HUP OR HANA OR ASR3935 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1167 Anabaena sp.])
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|DOMAIN=
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|RELATEDENTRY=[[1b8z|1B8Z]], [[1ihf|1IHF]], [[1p71|1P71]], [[1p78|1P78]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p51 OCA], [http://www.ebi.ac.uk/pdbsum/1p51 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p51 RCSB]</span>
}}
}}
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[[Category: protein-dna complex]]
[[Category: protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:19:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:54:54 2008''

Revision as of 19:54, 30 March 2008

Image:1p51.gif


PDB ID 1p51

Drag the structure with the mouse to rotate
, resolution 2.50Å
Ligands: , , ,
Gene: HUP OR HANA OR ASR3935 (Anabaena sp.)
Related: 1B8Z, 1IHF, 1P71, 1P78


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Anabaena HU-DNA cocrystal structure (AHU6)


Overview

HU and IHF are members of a family of prokaryotic proteins that interact with the DNA minor groove in a sequence-specific (IHF) or non-specific (HU) manner to induce and/or stabilize DNA bending. HU plays architectural roles in replication initiation, transcription regulation and site-specific recombination, and is associated with bacterial nucleoids. Cocrystal structures of Anabaena HU bound to DNA (1P71, 1P78, 1P51) reveal that while underlying proline intercalation and asymmetric charge neutralization mechanisms of DNA bending are similar for IHF and HU, HU stabilizes different DNA bend angles ( approximately 105-140 degrees ). The two bend angles within a single HU complex are not coplanar, and the resulting dihedral angle is consistent with negative supercoiling. Comparison of HU-DNA and IHF-DNA structures suggests that sharper bending is correlated with longer DNA binding sites and smaller dihedral angles. An HU-induced bend may be better modeled as a hinge, not a rigid bend. The ability to induce or stabilize varying bend angles is consistent with HU's role as an architectural cofactor in many different systems that may require differing geometries.

About this Structure

1P51 is a Single protein structure of sequence from Anabaena sp.. Full crystallographic information is available from OCA.

Reference

Flexible DNA bending in HU-DNA cocrystal structures., Swinger KK, Lemberg KM, Zhang Y, Rice PA, EMBO J. 2003 Jul 15;22(14):3749-60. PMID:12853489

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