5ad3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Bivalent binding to BET bromodomains== | |
| - | + | <StructureSection load='5ad3' size='340' side='right' caption='[[5ad3]], [[Resolution|resolution]] 1.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ad3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AD3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AD3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K6K:3-METHOXY-N-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)-4-PIPERIDYL]PHENOXY]ETHYL]-N-METHYL-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-AMINE'>K6K</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ad2|5ad2]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ad3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ad3 OCA], [http://pdbe.org/5ad3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ad3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ad3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ad3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bobby, R]] | ||
| + | [[Category: Boiko, S]] | ||
| + | [[Category: Bradbury, R H]] | ||
| + | [[Category: Callis, R]] | ||
| + | [[Category: Chen, H]] | ||
| + | [[Category: Dale, I]] | ||
| + | [[Category: Daniels, D]] | ||
| + | [[Category: Flavell, L]] | ||
| + | [[Category: Holdgate, G]] | ||
| + | [[Category: Jowitt, T A]] | ||
| + | [[Category: Kikhney, A]] | ||
| + | [[Category: McAlister, M]] | ||
[[Category: Ogg, D]] | [[Category: Ogg, D]] | ||
| + | [[Category: Patel, J]] | ||
| + | [[Category: Petteruti, P]] | ||
| + | [[Category: Rabow, A A]] | ||
| + | [[Category: Robb, G R]] | ||
| + | [[Category: Robers, M]] | ||
| + | [[Category: Stratton, N]] | ||
| + | [[Category: Svergun, D I]] | ||
[[Category: Walker, G]] | [[Category: Walker, G]] | ||
[[Category: Wang, W]] | [[Category: Wang, W]] | ||
| - | + | [[Category: Waring, M J]] | |
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| - | [[Category: Waring, M | + | |
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[[Category: Whittaker, D]] | [[Category: Whittaker, D]] | ||
| - | [[Category: | + | [[Category: Transcription]] |
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Revision as of 17:00, 3 October 2016
Bivalent binding to BET bromodomains
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Categories: Bobby, R | Boiko, S | Bradbury, R H | Callis, R | Chen, H | Dale, I | Daniels, D | Flavell, L | Holdgate, G | Jowitt, T A | Kikhney, A | McAlister, M | Ogg, D | Patel, J | Petteruti, P | Rabow, A A | Robb, G R | Robers, M | Stratton, N | Svergun, D I | Walker, G | Wang, W | Waring, M J | Whittaker, D | Transcription
