1p79
From Proteopedia
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|PDB= 1p79 |SIZE=350|CAPTION= <scene name='initialview01'>1p79</scene>, resolution 1.10Å | |PDB= 1p79 |SIZE=350|CAPTION= <scene name='initialview01'>1p79</scene>, resolution 1.10Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=K:POTASSIUM ION'>K</scene> | + | |LIGAND= <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p79 OCA], [http://www.ebi.ac.uk/pdbsum/1p79 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p79 RCSB]</span> | ||
}} | }} | ||
| Line 25: | Line 28: | ||
[[Category: Sundaralingam, M.]] | [[Category: Sundaralingam, M.]] | ||
[[Category: Xiong, Y.]] | [[Category: Xiong, Y.]] | ||
| - | [[Category: K]] | ||
[[Category: bulge]] | [[Category: bulge]] | ||
[[Category: rna]] | [[Category: rna]] | ||
[[Category: tetraplex]] | [[Category: tetraplex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:55:54 2008'' |
Revision as of 19:55, 30 March 2008
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| , resolution 1.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex
Overview
Bulges are an important structural motif in RNA and can be used as recognition and interaction sites in RNA-protein interaction and RNA-RNA interaction. Here we report the first crystal structure of a bulged RNA tetraplex at 1.1 A resolution. The hexamer r(U)(BrdG)r(UGGU) forms a parallel tetraplex with the uridine sandwiched by guanines bulging out. The bulged uridine adopts the syn glycosidic conformation and its O2 and N3 atoms face outwards, serving as an effective recognition and interaction site. The bulge formation both widens the groove width and changes the groove hydrogen-bonding pattern on its 5' side. However, the bulge does not make any bends or kinks in the tetraplex structure. The present study demonstrates the dramatic difference between uridine and guanine in forming tetraplex structure. In addition, both G(syn) tetrad and G(anti) tetrad have been observed. They display the same base-pairing pattern and similar C1'-C1' distance but different hydrogen-bonding patterns in the groove.
About this Structure
1P79 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Crystal structure of a bulged RNA tetraplex at 1.1 a resolution: implications for a novel binding site in RNA tetraplex., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Nov;11(11):1423-30. PMID:14604532
Page seeded by OCA on Sun Mar 30 22:55:54 2008
Categories: Protein complex | Pan, B. | Shi, K. | Sundaralingam, M. | Xiong, Y. | Bulge | Rna | Tetraplex
