1p86
From Proteopedia
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|PDB= 1p86 |SIZE=350|CAPTION= <scene name='initialview01'>1p86</scene> | |PDB= 1p86 |SIZE=350|CAPTION= <scene name='initialview01'>1p86</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1gix|1GIX]], [[1giy|1GIY]], [[1jj2|1JJ2]], [[1ibl|1IBL]], [[1lnr|1LNR]], [[1m5g|1M5G]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p86 OCA], [http://www.ebi.ac.uk/pdbsum/1p86 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p86 RCSB]</span> | ||
}} | }} | ||
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[[Category: real-space refinement]] | [[Category: real-space refinement]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:56:13 2008'' |
Revision as of 19:56, 30 March 2008
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| Ligands: | , , , | ||||||
| Related: | 1GIX, 1GIY, 1JJ2, 1IBL, 1LNR, 1M5G
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the initiation-like state of E. coli 70S ribosome
Overview
Cryo-EM density maps showing the 70S ribosome of E. coli in two different functional states related by a ratchet-like motion were analyzed using real-space refinement. Comparison of the two resulting atomic models shows that the ribosome changes from a compact structure to a looser one, coupled with the rearrangement of many of the proteins. Furthermore, in contrast to the unchanged inter-subunit bridges formed wholly by RNA, the bridges involving proteins undergo large conformational changes following the ratchet-like motion, suggesting an important role of ribosomal proteins in facilitating the dynamics of translation.
About this Structure
1P86 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Study of the structural dynamics of the E coli 70S ribosome using real-space refinement., Gao H, Sengupta J, Valle M, Korostelev A, Eswar N, Stagg SM, Van Roey P, Agrawal RK, Harvey SC, Sali A, Chapman MS, Frank J, Cell. 2003 Jun 13;113(6):789-801. PMID:12809609
Page seeded by OCA on Sun Mar 30 22:56:13 2008
