1p9s

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|PDB= 1p9s |SIZE=350|CAPTION= <scene name='initialview01'>1p9s</scene>, resolution 2.54&Aring;
|PDB= 1p9s |SIZE=350|CAPTION= <scene name='initialview01'>1p9s</scene>, resolution 2.54&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=DIO:1,4-DIETHYLENE DIOXIDE'>DIO</scene>
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|LIGAND= <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= ORF1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Human coronavirus])
|GENE= ORF1a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Human coronavirus])
 +
|DOMAIN=
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|RELATEDENTRY=[[1lvo|1LVO]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9s OCA], [http://www.ebi.ac.uk/pdbsum/1p9s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p9s RCSB]</span>
}}
}}
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[[Category: Wadhwani, P.]]
[[Category: Wadhwani, P.]]
[[Category: Ziebuhr, J.]]
[[Category: Ziebuhr, J.]]
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[[Category: DIO]]
 
[[Category: coronavirus]]
[[Category: coronavirus]]
[[Category: hcov]]
[[Category: hcov]]
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[[Category: tgev]]
[[Category: tgev]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:21:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:56:55 2008''

Revision as of 19:56, 30 March 2008

Image:1p9s.jpg


PDB ID 1p9s

Drag the structure with the mouse to rotate
, resolution 2.54Å
Ligands: ,
Gene: ORF1a (Human coronavirus)
Related: 1LVO


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs


Overview

A novel coronavirus has been identified as the causative agent of severe acute respiratory syndrome (SARS). The viral main proteinase (Mpro, also called 3CLpro), which controls the activities of the coronavirus replication complex, is an attractive target for therapy. We determined crystal structures for human coronavirus (strain 229E) Mpro and for an inhibitor complex of porcine coronavirus [transmissible gastroenteritis virus (TGEV)] Mpro, and we constructed a homology model for SARS coronavirus (SARS-CoV) Mpro. The structures reveal a remarkable degree of conservation of the substrate-binding sites, which is further supported by recombinant SARS-CoV Mpro-mediated cleavage of a TGEV Mpro substrate. Molecular modeling suggests that available rhinovirus 3Cpro inhibitors may be modified to make them useful for treating SARS.

About this Structure

1P9S is a Single protein structure of sequence from Human coronavirus. Full crystallographic information is available from OCA.

Reference

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs., Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R, Science. 2003 Jun 13;300(5626):1763-7. Epub 2003 May 13. PMID:12746549

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