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5dzp
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T206 in conformation B== | |
| - | + | <StructureSection load='5dzp' size='340' side='right' caption='[[5dzp]], [[Resolution|resolution]] 2.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5dzp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DZP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6B7:(2~{R},3~{R},4~{R})-4-METHYL-3-(2-OXIDANYLIDENE-2-PROPOXY-ETHYL)SULFANYL-5-[(2~{S},3~{R})-3-OXIDANYL-1-OXIDANYLIDENE-BUTAN-2-YL]-3,4-DIHYDRO-2~{H}-PYRROLE-2-CARBOXYLIC+ACID'>6B7</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dzj|5dzj]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dzp OCA], [http://pdbe.org/5dzp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dzp RCSB], [http://www.ebi.ac.uk/pdbsum/5dzp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dzp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LDT2_MYCTU LDT2_MYCTU]] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.<ref>PMID:24041897</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ginell, S L]] | ||
[[Category: Kumar, P]] | [[Category: Kumar, P]] | ||
| - | [[Category: Ginell, S.L]] | ||
[[Category: Lamichhane, G]] | [[Category: Lamichhane, G]] | ||
| + | [[Category: Cell wall enzyme]] | ||
| + | [[Category: Peptidoglycan synthesis enzyme]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 21:24, 5 October 2016
Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T206 in conformation B
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